ALBRIOZA Commercial Launch

Team Deeply Experienced Executive Team to Oversee Global Growth, Clinical Development, Approvals, and Commercial Execution Joshua Cohen BSE Co-CEO and Director Co-invented AMX0035, dedicated to ALS/neurodegenerative research since 2013, co-designed CENTAUR study, co-led development of AMX0035 as 3-person company for 6 years, then built Amylyx team Tammy Sarnelli Global Head of Regulatory Affairs 30+ years in Regulatory, including at Biogen leading approvals of Tysabri and Tecfidera Former Head of Global Regulatory Affairs, Neurology & Immunology at EMD Serono Keith White Head of Global Market Access 20+ years in Market Access, including at Genentech, Intermune, and Intercept Justin Klee ScB Co-CEO and Director Co-invented AMX0035, dedicated to ALS/neurodegenerative research since 2013, co-designed CENTAUR study, co-led development of AMX0035 as 3-person company for 6 years, then built Amylyx team Debra Canner Chief HR Officer Former CHRO at Akamai, Juniper, several others; VP HR at Genzyme Timothy Lee Head of US Commercial Development and Global Commercial Training 20+ years of sales, marketing and product commercialization experience, including at Alexion Pharmaceuticals, Novartis, and Pfizer Jim Frates Chief Financial Officer 22-year CFO at Alkermes; grew to >$1B in annual revenue and >2,000 employees worldwide Tom Holmes Global Head of Supply Chain Former Head of Global External Manufacturing at Biogen Maryellen Garrett Head of Global Accounting and Finance Operations CPA with 20+ years of finance and accounting experience, including at Entasis Therapeutics, Cubist Pharmaceuticals and PWC Shauna Horvath Head of Global Marketing 15+ years of marketing experience, including at Cambridge BioMarketing Margaret Olinger, MBA Chief Commercial Officer 2nd commercial employee at Alexion; helped oversee launch of Soliris and Strensiq at Alexion. 30+ years in commercial John Landry Head of Commercial Operations 25+ years of sales and operations experience, including at Akcea Therapeutics, Alexion Pharmaceuticals and Novartis Gina M. Mazzariello Chief Legal Officer and General Counsel 20+ years of corporate and commercial legal experience within the healthcare industry, including at Boehringer Ingelheim Patrick Yeramian, MD, MSC, MBA Chief Medical Officer Over 25 years as clinical trialist, CMO, and clinical consultant including as CMO of Viragen Machelle Manuel, PhD Head of Global Medical Affairs Former Head of Global Medical Scientific Affairs at Ironwood 20+ years in medical affairs AMYLYX 34

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