Investor Presentaiton

Model for the immuno-suppressive effect of CD28 shedding Stimulation of T cells CD28 shedding from activated T cells CD80 CD86 T cell APC Pro-MMPs sCD28 CD28 MMPs sCD28 T cell sCD28 serves as a decoy receptor CD80 CD86 sCD28 CD28 T cell APC MMPs BIOND BIOLOGICS Activated T cell During the stimulation of T cells, Matrix Metalloproteinases (MMPs) are upregulated and cleave CD28 at its stalk region, releasing a dimeric soluble CD28. Anergic T cells SCD28 acts as a decoy receptor by binding to CD28 cognate ligands, CD80 and CD86 on antigen presenting cells (APC). Activated T cells with lower membranal CD28 density and insufficient B7 mediated signaling become anergic and cannot generate proper immune response against malignant cells. Biond Biologics Corporate Presentation | May 2021 | Non-confidential 17

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