First Quarter 2018 Investor Presentation

Investor Presentation First three months of 2018 Slide 79 The healthcare cost associated with obesity expected to increase Global healthcare costs related to obesity expected to increase by 50% by 2025 +50% USD ~0.8 trillion USD ~1.0 trillion USD ~1.2 trillion • • • • Increase in healthcare costs primarily driven by obesity-related comorbidities Today, 650 million people have obesity globally By 2025, ~1 billion people are expected to have obesity If left untreated, by 2025, the costs of treating complications of obesity is expected to reach USD ~550 billion in the US and USD ~1.2 trillion globally The increased healthcare costs are primarily driven by obesity-related comorbidities such as type 2 diabetes and cardiovascular disease 2017 Source: World Obesity Federation, 2017 changing diabetes 2020 2025 Source: WHO, October 2017; World Obesity Federation, 2017 novo nordisk

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