Kymera IPO Presentation Deck

KYMERA Degradation of IRAK4, Ikaros and Aiolos Correlates to Cell Killing IMID Degrader CRBN IMD Rinder Degradation of ID Substrates IRAKIMID Degrader CRBN iped IMD Binder Degradation of IMID Substrates and A IRAKA - IRAK4, Ikaros and Aiolos degradation measured in MYD-88- mutated OCI-Ly10 cells after 24 h of drug exposure - IRAK4 DC50=4 nM • Ikaros/Aiolos DC5o = 2/2 nM Degradation correlates with cell killing effects IC50=31 nM % Cell Death 100- 50 0 10000'0 0.0001 0.001 0.01 0.1 % Cell Death Aiolos Ikaros IRAK4 10 -50 100 0 100 IRAKIMID Degrader Concentration (µM) % Degradation

View entire presentation