Acquisition of APIRx
For personal use only
Why cannabinoid oral delivery via medicated
chewing gum and chewable tablets
Medicated chewing gum and chewable tablets ('MCGT') is a drug delivery system growing in favour
amongst the medical community due to widespread potential applications as an extended-release
dosage form that provides a continuous release of the medicine contained. MCGTs are fast acting
as they release the active ingredients into the oral mucosa, reducing the potential for gastric
intolerance amongst patients. These qualities, amongst others, make MCGTs an excellent delivery
system for medicinal combinations designed to treat sustaining pain and addiction disorders.
Extended release of cannabinoid and other
pharmaceutical ingredients while chewing.
APIRX have a patented procedure for conversion
of cannabinoids to their hydrophilic form.
Well tolerated by patients.
No capsules to swallow or
messy liquids to administer.
Incannex
Cannabinoid absorbed via oral mucosa (mouth)
Avoids first pass metabolism in the liver, a major factor
that reduces the oral bioavailability of cannabinoids.
Avoids gastrointestinal intolerance
of pharmaceutical ingredients.
Increased bioavailability leads to increased therapeutic
effect and/or reduced cost of goods due to reduced dose.
Benefits of
Mastication*
Improved cerebral
circulation
Anxiety reduction effect:
De-stress or "eustress"
Hypothalamic-hypophyseal-
adrenal axis (HPA)
coordination/ attenuation
Memory coordination/
improvement
Neuroprotection
- Analgesic effect
"Physical exercise" effect
* Weijenberg, Roxane Anthea Francesca,
and Frank Lobbezoo. "Chew the pain away:
oral habits to cope with pain and stress and
to stimulate cognition." BioMed research
international 2015 (2015).
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