BioNTech Results Presentation Deck

Data Demonstrates Protection Against Circulating SARS-CoV-2 Variants Including Delta Variant Neutralizing antibody titers Reduced, yet preserved in vitro neutralizing activity of immune sera against several variants of concern, including: Alpha, Gamma, Beta, Eta, Delta 1, 2, 3 16 1,2801 log₂ PRNT 50 640- 320- 160- 80- 40- 20+ 502 157 ACOAX 355 343 0200000 amores 331 MODACO USA- B.1.617.1- B.1.617.2- B.1.617.2.v2- B.1.618- WA1/2020 spike spike spike spike LOD Poly-specific T cell responses Vaccinated individuals generate a T cell response targeting epitopes conserved across a number of variants, including the Delta variant²,4 84 BNT162b2 B. 1.617.2 (Delta) B. 1.1.7 (Alpha) B. 1.351 (Beta) P. 1 (Gamma) 92 269 Public Health England, NEJM July 20215; preprint July 20216 Public Health Ontario, Canada, preprint July 20217 277 321 Public Health Scotland, Lancet June 20218 Israel, MoH⁹ 329 448 Timepoint ≥14d post 2d - up to 2-3m ≥7d post 2d - up to 1-2m LPFNDGVYF YLQPRTFLL QPTESIVRF NYNYLYRLF IPFAMOMAY RLQSLQTYV QYIKWPWYI KWPWYIWLGF LPFNDGVYF YLQPRTFLL QPTESIVRF NYNYRFRLF IPFAMOMAY RLQSLQTYV QYIKWPWYI KWPWYIWLGF LPFNDGVYE YLQPRTFLL QPTESIVRF NYNYLYRLF IPFAMQMAY RLQSLQTYV QYIKWPWYI KWPWYIWLGF LPFNDGVYF YLQPRTFLL QPTESIVRF NYNYLYRLF IPFAMOMAY RLQSLOTYV QYIKWPWYI KWPWYIWLGF LPFNDGVYE YLQPRTFLL QPTESIVRF NYNYLYRLF IPFAMOMAY RLQSLQTYV QYIKWPWYI KWPWYIWLGF Real world data Observed effectiveness against variants of concern including Delta variant (95% CI) Hospitalization Real-World Infection Symptomatic 96 (86-99) ≥14d post 2d - up to 2-3m 456 896 ≥7d post 2d - up to 6m 88 (78-93) 79 (75-82) 904 1000 39 (9-59) 1008 1208 87 (64-95) 41 (9-61) 1. Liu J et al Nature 2021https://www.nature.com/articles/s41586-021-03693-y. 2. Xie X et al Nature Med https://doi.org/10.1038/s41591-021-01270-4 2021. 3. Liu J et al Nature Med 2021 https://doi.org/10.1038/s41586-021-03693-y. 4. Sahin U et al Nature 2021 https://www.nature.com/articles/s41586-021-03653-6 5. Bernal et al. NEJM 2021 https://www.nejm.org/doi/pdf/10.1056/NEJMoa2108891?article Tools=true 6. Stowe et al (preprint) available from https://media.tghn.org/articles/Effectiveness of COVID- 19 vaccines against hospital_admission_with_the_Delta B. G6gnnqJ.pdf 7. Nasreen et al MedRxiv preprint 10.1101/2021.06.28.21259420 8. Sheikh et al. Lancet 2021 doi: 10.1016/S0140- 6736(21)01358-1; 9. Press release Israel MoH https://www.gov.il/Blob Folder/reports/vaccine-efficacy-safety-follow-up-committee/he/files_publications_corona_two-dose-vaccination-data.pdf 1216 1211 100 1220 88 (79-93) BIONTECH

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