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Investor Presentaiton

Financial Results for Q4 FY2022 Marketing Status of ORGOVYX® Approx. 5,000 new patients started treatment with ORGOVYX® in Q4 FY2022 (19% growth vs. Q3 FY2022) +19% 31,000 26,000 22,000 18,000 14,500 11,000 8,000 4,500 ■The market for androgen deprivation therapy targeted by ORGOVYX® is over 200 billion yen/year (gross conversion), and recently expanded by approx. 20% annually* ■Established broad health plan coverage (Percentage of coverage obtained as of April 2023: total of Medicare Part D lives was approx. 100%, total of commercial lives was >90%) ■ Gathering new evidence for further potential utility (Use in combination therapy and cardiovascular event Q1 Q2 Q3 FY2021 FY2021 FY2021 FY2021 FY2022 FY2022 FY2022 Q4 Q1 Q2 Q3 Q4 FY2022 risks) Estimated Cumulative Patients Treated with ORGOVYX® (includes patients on free and commercial drug, excludes patients utilizing product samples) *Source IQVIA *NSP sales for RELUGOLIX, DEGARELIX, GOSERELIN, LEUPROLIDE, and TRIPTORELIN for the 12 months ended Feb. 2023 were $1,612M (130yen/$), which reflects a 21% growth vs the 12 months ended Feb. 2022
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