Investor Presentaiton

Investor presentation First three months of 2017 Diabetes - the inability to manage blood sugar levels appropriately Slide 31 Facts about diabetes Diabetes is a chronic disease that occurs either when the pancreas does not produce enough insulin or when the body cannot effectively use the insulin it produces Primary classifications: Type 1 diabetes: Complete insulin deficiency due to destruction of beta-cells in the pancreas Type 2 diabetes: Characterised by some degree of insulin resistance and insulin deficiency Insulin: • Facilitates uptake of blood sugar into cells . Inhibits glucose release from the liver The aim of insulin therapy is to recreate normal blood insulin profile meal-related peaks (prandial) 70 T Short-lived, rapidly generated 60- 긑 50- Insulin (U/mL) 40- 20- 10- Sustained Insulin profile (basal) Fat cell Liver Pancreas Muscle changing diabetes® 0- 6:00 10:00 14:00 18:00 22:00 2:00 6:00 1 Time of day Breakfast Lunch Dinner novo nordisk

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