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Investor Presentaiton

KEY EVENTS SINCE THE LAST EARNINGS CALL Lilly REGULATORY . • • • Announced the completed regulatory submission of tirzepatide for chronic weight management to the FDA; Announced the regulatory submission of donanemab for traditional approval for early Alzheimer's disease in the US and EU; Announced mirikizumab received approval in the European Union (EU) for patients with ulcerative colitis and the resubmission to the FDA; Announced the submission of JaypircaⓇ to the FDA for accelerated approval in CLL patients based on the Phase 1/2 BRUIN study; Completed the submission of pirtobrutinib for relapsed or refractory mantle cell lymphoma in Japan; and Announced the FDA approval of Jardiance®1 to lower blood sugar along with diet and exercise in children 10 years and older with type 2 diabetes. CLINICAL Presented data at the 2023 Alzheimer's Association International Conference which showed that donanemab significantly slowed cognitive and functional decline in people with early symptomatic Alzheimer's disease; and Announced topline data from two tirzepatide Phase 3 trials, SURMOUNT-3 and SURMOUNT-4, in which tirzepatide demonstrated significant and superior weight loss compared to placebo in both studies. OTHER • Announced an agreement to acquire DICE Therapeutics, a biopharmaceutical company that develops novel oral therapeutic candidates to treat chronic diseases in immunology; Announced an agreement to acquire Versanis Bio, a private clinical-stage biopharmaceutical company focused on the development of new medicines for the treatment of cardiometabolic diseases; Announced an agreement to acquire Sigilon Therapeutics, a biopharmaceutical company that seeks to develop functional cures for patients with a broad range of acute and chronic diseases; and Allocated an additional $50 million to our now $300 million Social Impact Venture Capital Portfolio, reflecting Lilly's commitment to going beyond the medicines it makes to have a positive impact on patients and society through for-profit investments. 1 Jardiance is part of the Boehringer Ingelheim (BI) and Lilly Alliance, and BI holds the marketing authorization for Jardiance Not for promotional use 2023 Q2 EARNINGS 5
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