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Pharma Update

Product Development Continued commitment to delivering the worlds most impactful medicines Selected Product Development Leaders R&D Excellence Clinical Science Oncology & Hematology Charlie Fuchs Head of PD/CMO Levi Garraway Medical Affairs Stefan Frings Clinical Science Neuroscience & Rare Diseases, Immunology, Infectious Disease & Ophthalmology Paulo Fontoura 1 2 × Set ambitious R&D objectives 4 5 Access the best external innovation R&D productivity Success rate ✓ Value R&D productivity R&D Research and development Costs ✓ Cycle time Strengthen portfolio framework 3 6 Transform portfolio management & governance Optimize R&D engines and invest in emerging technologies Evolve talent, culture and mindset to achieve objectives Volume Effectiveness Roche Efficiency 68
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