Fourth Quarter Highlights

Asset Quality Net Charge-Offs/Average Loans 2.00% 1.74% 1.66% 1.50% 0.96% 1.00% 0.98% 0.52% 0.26% 0.50% 0.29% 0.20% 0.41% 0.41% 0.17% 0.21% 0.17% 0.16% 0.15% 0.20% 0.16% 0.23% 0.00% 0.18% 0.14% 0.18% 0.16% 0.14% ($ in millions) 0.10% 0.16% Net Charge-Offs 0.04% 0.05% 0.08% 0.08% 0.03% 0.03% 0.02% 0.01% (2) (2) $31.9 (3) $29.7(3) $5.6 $7.6 $13.9 $13.9 $20.1 $5.2 $5.1 $2.5 $4.8 $6.9 $15.6 $14.0 $3.3 $4.8 $0.8 $0.6 (3) (3) Net PCD Recoveries $46.3 (3) $24.6(3) (3) $8.2 $1.75) $6.2(3) 20 20 2007 2008 2009 2010 2011 (1) 2012 2013 2014 2015 2016 UBPR Peer Group 2017 2018 2019 2020 2021 2022 4Q21 4Q22 Prosperity Bank (3) Non-Acquired Loan Charge-Offs Acquired Loan Charge-Offs Pre-CECL Note: NPAs include loans past due 90 days and still accruing (3) 223 (1) (2) Source: Company Documents & Uniform Bank Performance Report UBPR = Uniform Bank Performance Report; Peer Group 2 (111 banks) - Insured commercial banks having assets between $10 billion and $100 billion Interim period net charge-off ratios shown on an annualized basis Reflects all charge-offs and recoveries on acquired loans in accordance with CECL accounting practices; Prior to the adoption of CECL in the first quarter of 2020, PCD loans were classified as Purchased Credit Impaired (PCI) loans and their assigned fair-value marks were netted against the outstanding loan balance with a charge-off only being recorded when the loss exceeded the amount of fair-value marks remaining. Acquired Loan Charge-Offs Post-CECL Net PCD Recoveries Post-CECL (3) PB LISTED NYSE

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