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Investor Presentaiton

Continued Strong Pipeline Execution 2023 Key Milestones Early Stage: Opdivo Neo-adjuvant NSCLC Ph3 (CM-816) approval in EU iberdomide (+/- Yervoy) Initiation of pivotal post-transplant maintenance H2H vs Revlimid 2024/2025 Key Milestones Metastatic: 1L HCC Ph3 (CM-9DW) Reblozyl 1L+ MSI High CRC Ph3 (CM-8HW) 1L MF Ph3 (INDEPENDENCE) EoE Ph3 cendakimab Metastatic: Early Stage: Sotyktu PSA Ph3 X 1L mCRPC Ph3 (CM-7DX) Reblozyl 1L MDS (COMMANDS) U.S. filing Opdualag 1L NSCLC Ph21 Opdivo (+/- Yervoy) Peri-adj NSCLC Ph3 (CM-77T) Zeposia ☐ Peri-adj MIBC Ph3 CD maintenance Ph3 (YELLOWSTONE) ROS1+ NSCLC (TRIDENT-1) Mod-to-severe PsO (CM-078) repotrectinib U.S. filing EU approval Sotyktu X CD Ph2 (IM011-023) 3-5L MM Ph3 (KarMMa-3) × UC Ph2 (IM011-127) filing Abecma Initiation NDMM Ph3 LPA₁ (KarMMa-9) Antagonist Initiation IPF Ph3 PPF Ph2 (IM027-040) 2L TE LBCL EU approval 3L+ CLL Ph1/2 Opdualag Camzyos OHCM EU approval Breyanzi (TRANSCEND-CLL) 3L+FL Ph2 (TRANSCEND- FL) LIBREXIA (milvexian) Initiation Ph3 program² alnuctamab BCMA TCE Adj HCC Ph3 (CM-9DX) Stage III Unresectable NSCLC Ph3 (CM-73L) ☐ Adj NSCLC Ph3 (ANVIL, co-op group) 1L HCC Ph2 X 2L+ HCC Ph2 2L/3L+ MSS mCRC Ph3 Initiation MM Ph3 ll Bristol Myers Squibb Q3 2023 Results 1. Data readout anticipated early 2024 2. ACS, SSP, AF trials conducted by Janssen Milestones represent data readouts unless otherwise specified; subject to positive registrational trials and health authority approval Not for Product Promotional Use 10
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