Investor Presentaiton
sanofi
Therapeutic vaccine addressing multiple pathogenic mechanisms
Acne vulgarum: skin dysbiosis
driven by outgrowth of pathogenic
Cutibacterium acnes
Corneocyte
Sebum
C.acnes
C. acnes
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Bacterial Virulence Factors
Origimm Antigens
Expressed on surface of pathogenic
C. acnes strains
-
Induce opsonophagocytic killing
antibodies to reduce bacterial burden
Essential adhesin and iron uptake
functionality
Additional Vaccine Antigen
-
Based on key bacterial
virulence factor
Keratinocytes
Immune Cells
Sebocytes
-
Induces antibodies that
neutralize the virulence factor,
interrupting the inflammatory
cascade that drives disease
Inflammatory cascade
Pharmaceutics 2019, 11(10), 490; https://doi.org/10.3390/pharmaceutics11100490 Targeted Topical Delivery of Retinoids in the Management of Acne Vulgaris: Current Formulations and Novel Delivery Systems by Gemma Latter
108 Vaccines Investor EventView entire presentation