Kymera Investor Day Presentation Deck

IRAK4 is a key initiator of Type 2 and Type 17 inflammation of mucosal tissues via TLRS and IL-1 family receptors Upstream initiation Downstream effects Tissue effects Amplification Virus Bacteria Allergens Epithelial Injury becobet IL-33 Activation TLR SANOFI APC IL-1 a/B, IL-36 IRAK4 signaling Tho Th2 Th17 I I IL-5 IL-4, IL-13 Differentiation in bone marrow Th cells T helper cells; IgE: Immunoglobulin E Source: https://www.type2inflammation.com/science-cytokines Amplification Class switching IL-6 IL-17 Eosinophil Th2 B cell IgE Trafficking to tissues Neutrophil Mucus secretion, hyperplasia, collagen deposition Immunity. 2019 Apr 16;50(4):778-795 I I I I I I I I Allergens Maladaptation Degranulate Mast cell Basophil CARBUROOO Asthma COPD Airway obstruction & hyperreactivity Skin thickening, itch & inflammation Atopic Dermatitis Hidradenitis Sup. Cut. Lupus Colonic mucosal inflammation Ulcerative Colitis Crohn's Disease

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