Connecting Innovation to Purpose

13 CRB-701: Next generation site-specific Nectin-4 targeting ADC Novel nectin-4 Antibody ADCC + CDC functionality Glutamine focused side chain conjugation MMAE = Monomethyl auristatin E ADCC = antibody-dependent cellular cytotoxicity CDC complement dependent cytotoxicity O H Cathepsin-B cleavage site H₂N NH Payload Monomethyl auristatin E [MMAE] Microtubule disruption NH OH Source(s): Modified image from Corbus data on file; Corbus data on file

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