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Investor Presentaiton

Cell Therapy Growth Spans the RMS Portfolio - Humanized and super-immunodeficient rodent models are critical for cell therapy development and preclinical safety assessment Many cell therapies are in the area of oncology, e.g. CAR-T therapies Strong presence in the key Cambridge and South San Francisco biohubs offering turnkey CRADLTM vivarium space Attracting a range of biopharma companies – small and large Additional synergies for CRADL TM from growing biotech clients providing new business opportunities in the GEMS business Additional synergies more broadly across CRL portfolio, particularly in DSA Cell Solutions provides materials that are a critical foundation to support cell therapy development process from research through commercialization Illustrates the highly bespoke nature of the in vivo models that clients use in their R&D programs Charles River Laboratories (CRL) 9
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