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Investor Presentaiton

R&D milestones in 2018 Project TresibaⓇ XultophyⓇ FiaspⓇ Q1 2018 DEVOTE and SWITCH² US regulatory decision DUAL I Japan Phase 3a ✓ DUAL II Japan Phase 3a ✓ OzempicⓇ Oral semaglutide EU and Japan regulatory decision PIONEER 1 data Phase 1 data Investor Presentation First nine months of 2018 Slide 15 Results available¹ Regulatory milestone Q2 2018 Q3 2018 Q4 2018 EU variation application pens PIONEER 2, 3, 4 and 7 data Japan submission Japan submission EU variation application SUSTAIN 7 PIONEER 5 and 10 data ✓ PIONEER 8 data PIONEER 6 and 9 data LAI287 AM833 Phase 1 data N8-GP US/EU submission N9-GP Concizumab Somapacitan Diabetes Obesity Haemophilia REAL 3 Phase 2, GHD data Growth disorders 1 Expected to be published in the given quarter or in the subsequent quarterly company announcement 2 Supplemental applications to include the two SWITCH trials have been withdrawn based on interactions with FDA GHD: Growth hormone deficiency; AGHD: Adult growth hormone deficiency Japan regulatory decision ✓ explorer5 data REAL 1 (extension) Phase 3, AGHD data Japan submission explorer4 data novo nordisk
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