Fourth-Quarter and Full-Year 2019 Orphan and Rheumatology Segment Results

KRYSTEXXA: The Only Medicine Approved for Uncontrolled Gout Rapidly Reverses Disease Progression (2) KRYSTEXXA Mechanism of Action (1) Urate Before and After KRYSTEXXA 10 Allantoin Converts urate to water-soluble allantoin; Renal excretion of allantoin is up to 10x more efficient than excretion of uric acid(3) (1) Uncontrolled gout is chronic gout refractory (unresponsive) to conventional therapies. (2) Sundy JS, Baraf HSB, Yood RA, et al. Efficacy and Tolerability of Pegloticase for the Treatment of Chronic Gout in Patients. (3) McDonagh EM, Thorn CF, Callaghan JT, Altman RB, Klein TE. Pharmacogenet Genomics. 2014;24(9):464-476. HORIZON 24

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