Q3 2020 Sales Performance

Currency gsk 2019 currency sales exposure US $ Euro € Japanese \ Other* • . 41 % 18% 6% 35 % The other currencies that each represent more than 1% of Group sales are: Australian Dollar, Brazilian Real, Canadian Dollar, Chinese Yuan, Indian Rupee, Russian Rouble. In total they accounted for 13% of Group revenues in 2019. 2020 Adjusted EPS ready reckoner US $ 10 cents movement in average exchange rate for full year impacts Adjusted EPS by approx. +/- 5.5% Euro € 10 cents movement in average exchange rate for full year impacts Adjusted EPS by approx. +/- 1.5% Japanese \ 10 Yen movement in average exchange rate for full year impacts Adjusted EPS by approx. +/- 1.0% If exchange rates were to hold at the closing rates on 31 March 2020 ($1.24/£1, 1.13/£1 and Yen 134/£1) for the rest of 2020, the estimated impact on 2020 Sterling turnover growth would be around flat and if exchange gains or losses were recognised at the same level as in 2019, the estimated impact on 2020 Sterling Adjusted EPS growth would also be around flat All expectations and targets regarding future performance should be read together with the "Outlook assumptions and cautionary statement" sections of the Fourth Quarter 2019 Results Announcement and the cautionary statement slide included with this presentation 22 82

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