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Investor Presentation

139 Investor presentation First six months of 2022 Solid sales growth driven by Diabetes and Obesity care DKK billion 150 Reported annual sales 2017-2021 +4.7%¹ 14% 15% 16% 100 17% 16% 86% 50 50 84% 85% 83% 84% 0 2017 2018 2019 2020 2021 Diabetes and Obesity care Rare disease 1 CAGR for 5-year period S&D: Sales and distribution; R&D: Research and development Note: The outlined expected developments are aspirations and not long-term financial targets السمر لام Expected development towards 2025 Gross margin Remain broadly stable Novo NordiskⓇ S&D cost ratio Gradually decline enabled by attractive sales growth R&D cost ratio 8 88 Administration cost ratio Gradually increase to expand and diversify pipeline Decline driven by efficiency gains Operating margin Remain broadly stable
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