Investor Presentation - First Six Months of 2021

15 Investor presentation First six months of 2021 Financial results - First six months of 2021 Novo NordiskⓇ In DKK million Sales Gross profit Gross margin Sales and distribution costs First six months of 2021 66,845 55,487 83.0% 16,257 53,723 First six Change Change months of 2020 (reported) (CER) 63,881 5% 12% 3% 84.1% 14,988 8% 15% Percentage of sales 24.3% 23.5% Research and development costs 7,888 7,068 12% 15% Percentage of sales 11.8% 11.1% Administration costs 1,836 1,754 5% 8% Percentage of sales 2.7% 2.7% Other operating income, net 255 227 12% Operating profit 29,761 30,140 (1%) 9% Operating margin 44.5% 47.2% Financial items (net) 1,094 (1,703) Profit before income tax 30,855 28,437 9% Income taxes 6,109 5,915 3% Effective tax rate 19.8% 20.8% Net profit 24,746 22,522 10% Diluted earnings per share (DKK) 10.71 9.58 12% CER: Constant exchange rates

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