Novo Nordisk Investor Presentation - First Nine Months of 2016

Investor presentation First nine months of 2016 Diabetes - the inability to manage blood sugar levels appropriately Slide 32 Facts about diabetes Diabetes is a chronic disease that occurs either when the pancreas does not produce enough insulin or when the body cannot effectively use the insulin it produces Primary classifications: Type 1 diabetes: Complete insulin deficiency due to destruction of beta-cells in the pancreas Type 2 diabetes: Characterised by some degree of insulin resistance and insulin deficiency Insulin: • Facilitates uptake of blood sugar into cells . Inhibits glucose release from the liver The aim of insulin therapy is to recreate normal blood insulin profile Insulin (μ U/mL) meal-related peaks (prandial) 70 T Short-lived, rapidly generated 60- 50- 40- 20- 10- Sustained Insulin profile (basal) Fat cell Liver Pancreas Muscle changing diabetes® 0+ 6:00 10:00 14:00 18:00 22:00 2:00 Breakfast Lunch Dinner T 6:00 Time of day novo nordisk

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