Investor Presentation - First Six Months of 2021

90 Investor presentation First six months of 2021 Insulin market size and volume share of growth and market share in International Operations Insulin market share and market size (DKK billion) Market growth A Market share Total 50% Long- Acting 35% Fast- 60% 15 acting Premix 77% 9 49% Human 80 28 Novo Nordisk Competitors 80% 60 -0.5% +0.8% 60% 2% +1.5% 40% -1% +0.5% Insulin volume: Share of growth and market share 20% 0.2% +1.5% 0% May -7.2% -0.5% 2018 NN market share Source: IQVIA, May 2021, LHS graph - Value, RHS Graph - Volume, MAT, all countries; Share of growth not depicted due to too high numbers; NN: Novo Nordisk Novo NordiskⓇ 15% 13% 11% 50% 9% 7% 5% 3% 3% 1% 2% -1% May 2021 Market growth (Right Axis) NN growth (Right Axis)

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