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Investor Presentaiton

Immunology LPA₁ Sotyktu CD19 NEX T LPA₁ signaling is central to the pathogenesis of fibrotic lung diseases 1. Epithelial cell apoptosis¹ LPA₁ signaling promotes apoptosis of alveolar epithelial cells Recurrent lung injury 2. Fibroblast recruitment2,3 LPA₁ signaling induces fibroblast chemotaxis to the site of injury LPA LPA₁ CYTOPLASM Profibrotic signaling 4. Fibroblast survival1 LPA₁ signaling increases fibroblast resistance to apoptosis 3. Fibroblast proliferation & activation 4,5 LPA₁ signaling stimulates fibroblast proliferation and collagen secretion 1. Funke M, et al. Am J Respir Cell Mol Biol. 2012;46(3):355-364. 2. Tager AM, et al. Nat Med. 2008;14(1):45-54. 3. Swaney JS, et al. Br J Pharmacol. 2010;160(7):1699-1713. Ill Bristol Myers Squibb™ 4. Cheng PTW, et al. J Med Chem. 2021 Nov 11;64(21):15549-15581. 5. Decato BE, et al. Respir Res. 2022;23(1):61. Not for Product Promotional Use 58
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