Investor Presentaiton
Immunology
LPA₁
Sotyktu
CD19 NEX T
LPA₁ signaling is central to the pathogenesis of fibrotic lung
diseases
1. Epithelial cell apoptosis¹
LPA₁ signaling promotes
apoptosis of alveolar
epithelial cells
Recurrent
lung injury
2. Fibroblast recruitment2,3
LPA₁ signaling induces
fibroblast chemotaxis to the
site of injury
LPA
LPA₁
CYTOPLASM
Profibrotic
signaling
4. Fibroblast survival1
LPA₁ signaling increases
fibroblast resistance to
apoptosis
3. Fibroblast proliferation &
activation 4,5
LPA₁ signaling stimulates
fibroblast proliferation and
collagen secretion
1. Funke M, et al. Am J Respir Cell Mol Biol. 2012;46(3):355-364. 2. Tager AM, et al. Nat Med. 2008;14(1):45-54. 3. Swaney JS, et al. Br J Pharmacol. 2010;160(7):1699-1713.
Ill Bristol Myers Squibb™ 4. Cheng PTW, et al. J Med Chem. 2021 Nov 11;64(21):15549-15581. 5. Decato BE, et al. Respir Res. 2022;23(1):61.
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