EVOLUTION AT MERCK - INVENTING FOR LIFE

EARLY STAGE - INCLUDING ADJUVANT / NEOADJUVANT - REPRESENTS SIGNIFICANT PORTION OF CANCER PREVALENCE Early stage HEAD AND NECK Early stage MELANOMA Metastatic Early stage Unknown Metastatic Unknown Early stage BLADDER RENAL Metastatic Unknown Early stage Early stage Metastatic Unknown BREAST LUNG Unknown Metastatic Unknown Metastatic 18 registrational trials across these tumor types and more, representing meaningful growth opportunity Source: SEER 2018: Cancer Prevalence by Stage in U.S. MERCK Mike Nally I INVENTING FOR LIFE 60

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