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Investor Presentation

1 1816 RENE LAENNEC INVENTS THE STETHOSCOPE 2 1846 JOHN HUTCHINSON DEVELOPS THE WATER SPIROMETER MEASURING VITAL CAPACITY Respiratory Diagnostics Market Overview Existing Lung Diagnostics. are Failing Us Over the last 200 years, advances in medical diagnostic technology have delivered dramatic benefits for mankind whilst advancements in lung diagnostics have stagnated. The current gold standard modality to diagnose lung dysfunction (Spirometry) was invented in the 1860s. The most recent significant advance in lung diagnostics, the CT, is 50 years old next year. Billions in R&D has been poured into cancer, heart and brain diagnostics, but lung health research has not increased at the rate of lung disease. 99% of all lung diagnostics globally are made up of these four tests: Spirometry X-ray 3 1895 ROENTGEN DISCOVERS THE USE OF X-RAYS IN MEDICAL IMAGING •VAGA 1903 WILLEM EINTHOVEN DISCOVERS ELECTROCARDIOGRAPHY (ECG/EKG) 1929 - HANS BERGER DISCOVERS HUMAN ELECTROENCEPHALOGRAPHY 1953-MEDICAL ULTRASONOGRAPHY - INGE EDLER 1960 - ECHOCARDIOGRAM - EDLER AND HERTZ 1965 FIRST COMMERCIAL ULTRASOUND 1971 SIR GODFREY HOUNSFIELD INVENTS THE FIRST COMMERCIAL CT SCANNER 1971 MAGNETIC RESONANCE IMAGING - RAYMOND VAHAN DAMADIAN 1976-FIRST COMMERCIAL PET SCANNER 9 10 11 12 1979 DEVELOPMENT OF SPECT 13 1990 - SEIJI OGAWA DEMONSTRATES THE FIRST fMRI • CT • Nuclear Medicine All trade off accuracy, sensitivity, cost and radiation exposure, while failing to provide a comprehensive insight into both the form and function of the patient's lungs. Existing lung diagnostics are decades out of date, are not fit for purpose and are ripe for displacement. Pg 6 Investor presentation 3 1800 1850 1900 1950 2000 13 4DMedical
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