Investor Presentaiton

Three R&D productivity objectives to drive long term sustainable growth 1 Increase & Sustain INDS 2 Increase Probability of Success 3 Ill Bristol Myers Squibb™ ~10 INDs per year Increase success rate from first-in-human to approval to -20% Reduce Cycle Times Achieve median of -6.5 years from first- in-human to approval Not for Product Promotional Use 12

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