Novo Nordisk Annual Report 2021

Contents Introducing Novo Nordisk Strategic Aspirations Key risks Management Consolidated statements Additional information. Purpose and sustainability (ESG) Driving a Sustainable Business Expectations of what it means to be a sustainable business are evolving rapidly. The COVID-19 pandemic, access to care and the climate crisis have accelerated demands for the private sector to demonstrate how it adds value to society and mitigates long-term risks. Given Novo Nordisk's central position in the healthcare ecosystem, our company is at the forefront of these challenges - and we are stepping up our commitments to patients and society as we further integrate sustainability into everything we do. Our key ESG topics In 2021, we completed a thorough process aimed at addressing materiality and prioritising our key Environmental, Social and Governance (ESG) topics. We identified key ESG topics across two dimensions: (1) how our activities impact society and planet and (2) how society and planet impact our activities. Those ESG topics that are of highest impact and materiality are covered in this integrated annual report. All applicable remaining ESG topics are covered via our reporting on relevant ESG standards and frameworks (please refer to the Sustainability Standards section on pages 22 and 23). The "Key ESG priorities" overview is meant to inform our ESG reporting in the future and will be refreshed regularly. Overall, we aim to progress towards zero environmental impact, be respected for adding value to society and ensure distinct core capabilities, evolve culture as well as maintain and build trust across the E, S and G dimensions. Novo Nordisk Annual Report 2021 11 43% decrease in our overall CO2 emissions compared to pre-COVID levels in 2019 31,846 children reached through our Changing Diabetes® in Children programme in 2021. This corresponds to an increase of 13% compared to 2020

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