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Investor Presentation First nine months of 2018 Slide 67 Novo Nordisk has strengthened its insulin volume market share in Region Latin America Region Latin America insulin market by segment Region Latin America modern and new- generation insulin volume shares Novo Nordisk Eli Lilly Sanofi Other Device penetration tMU CAGR volume¹: 10.4% 18 CAGR value¹: 7.8% 15 12 9 16 3 0 Aug 2013 - Modern insulin penetration Penetration 50% 70% 60% 40% Fast-acting 50% Premix 30% 40% 30% 20% Long-acting 20% 10% 10% 0% 0% Aug 2018 Aug 2013 1 CAGR for 5-year period Note: IQVIA covers the following 4 markets in Latin America (retail data): Argentina, Brazil, Colombia and Mexico Source: IQVIA monthly MAT data Aug, 2018 volume and value (DKK) figures Note: Only top-3 shown Source: IQVIA monthly MAT data Aug, 2018 volume figures, numbers do not add up to 100% due to roundings 45% 27% 16% 11% Aug 2018 novo nordisk

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