Ocuphire Pharma Investor Updates
P
20
Secondary Endpoint: Mean Pupil Diameter Over Time
Achieved Pupil Size ~2mm In Nyxol+LDP Consistent With 3-line Improvement In Near Vision
5.0
4.0
Mean Pupil Diameter (mm)
3.0
≥2.0
1.0
4.8
4.4
4.3
4.2
Daily Evening
Nyxol Dosing 12 hr
minimum interval
to Time 0
*** 4.5
3.1
Baseline
4.3
0
3.2
***
***
***
4.5
3.2
3.0
N
2.4
***
T
***
**
HH
4.4
1
3.2
2.5
2.1
Best Eye
Mean Pupil Diameter
***
***
**
H
КН
4.3
3.4
2.7
2.3
***
*** 3.3
***
4.4
3
3.1
2.5
***
T
***
***
4.4
2
-LDP (n=31)
Time (Hours)
-Placebo (n=43) Nyxol+LDP (n=43)-Nyxol (n=30)
Source: VEGA-1 TLR Table 14.2.12.1 Observed Values and Change from Baseline in Photopic Pupil Diameter by Time Point (PP Population)
3.3
4
3.3
2.7
*** 4.6
Statistics Compared to Nyxol+LDP arm
*p<0.05
**p<0.01
***p<0.0001
5
*** 3.6
**
6
3.3
2.9
Ocuphire
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