BioAtla IPO Presentation Deck

CAB Technology Leverages Differential pH of Cancer Cells bicatla Normal Human Environments Typically Have Alkaline pH Arterial Blood 7.4-7.45 Capillary Blood 7.35-7.4 Venous Blood 7.35-7.45 Bile 7.8 Saliva 6.0-7.4 Brain Heart 7.0-7.4 Gastric Secretion. 1.0-3.5 Liver 7.2 Pancreatic Secretion 8.0-8.3 • Small intestine Secretion 7.5-8.0 Skeletal Muscle 6.9-7.2 Urine. 4.5-8.0 Bone. 7.4 Antibodies cannot access Saliva, Gastric Secretions, or Urine pH of normal environments that antibodies access Segmented image Tumor Environments Are Acidic With Lower pH Levels pHLIP intensity heat map <pH6.5 1 CAB antibodies allow for selective targeting of cancer tumor cells, based on pH, while generally not binding to normal tissue 2+ Acidic Cells • 87% oxygenated cells . 68-82% replicating cells 27-41% non-dividing cells Tumor-stroma boundary 2 This leads to the potential for enhanced therapeutic exposure & reduced toxicity compared to traditional antibodies MIT Study: Rohani, et al (2019) CancerRes 79:1952. (eg. Breast Cancer Cells) 8

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