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Investor Presentaiton

23 Investor presentation Full year 2022 Sales growth of 16%, driven by the GLP-1 portfolio for diabetes and obesity treatment Novo Nordisk reported quarterly sales DKK billion by therapy Reported sales for the full year 2022 Reported sales and growth breakdown for the full year 2022 Novo NordiskⓇ 50 Rare Other Therapy Reported sales CAGR1: 9.2% Sales (mDKK) Growth Share of growth 40 40 Rare endocrine rare blood disorders disease Total GLP-12 83,371 42% 98% Long-acting insulin³ 16,741 -13% -10% disorders 1% Premix insulin+ 10,562 -10% -5% -5.1%1 4% 7% Fast-acting insulin 17,463 -7% -5% 30 Obesity Human insulin 0.4%¹ 8,186 -16% -6% care 9% Total insulin 52,952 -11% -26% 3.6%1 Other Diabetes care 3,225 -15% -2% 20 10.6 %1 Total Diabetes care 139,548 14% 69% Obesity care? 16,864 84% 30% 10 79% Diabetes and Obesity care 156,412 19% 99% Diabetes care Rare blood disorders 11,706 7% 3% 0 Q4 Other rare disease 2012 Rare endocrine disorders Rare blood disorders Q4 2022 Rare endocrine disorders⁹ Other Rare disease 10 Rare disease 7,138 -6% -2% 1,698 -3% 0% 20,542 1% 1% Diabetes and Obesity care Sales of DKK 177.0 billion (+26%) Total 176,954 16% 100% 1 CAGR for 10-year period; 2 Comprises Victoza®, Ozempic®, Rybelsus®; 3 Comprises TresibaⓇ, XultophyⓇ and Levemir®; 4 Comprises RyzodegⓇ and Novo MixⓇ; 5 Comprises FiaspⓇ and NovoRapidⓇ: 6 Primarily NovonormⓇ, needles and GlucaGen® HypoKitⓇ; 7 Comprises SaxendaⓇ and Wegovy®: 8 Comprises NovoSeven®, Novo Eight®, NovoThirteen®, Refixia®, and EsperoctⓇ: 9 Comprises Norditropin and Macrilen TM; 10 Primarily Vagifem® and ActivelleⓇ Note: Sales numbers are reported in Danish kroner; Growth is at constant exchange rate, except for total sales growth of 26%; Refixia® and NovoThirteenⓇ are launched as RebinynⓇ and TRETTENⓇ, respectively, in North America.
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