Q2 2021 Results - Reimagining Medicine slide image

Q2 2021 Results - Reimagining Medicine

Participants Financial review Conclusion Appendix Company overview Pharmaceuticals Oncology Financial performance Innovation: Pipeline overview Novartis submission schedule Supplementary indications for existing brands References Innovation: Clinical trials 2021 alpelisib LCM BYL719 PROS Beovu LCM brolucizumab, RTH258 DME canakinumab¹ LCM Cosentyx 2022 secukinumab, AIN457 PSA IVIV Cosentyx secukinumab, AIN457 AS H2H Cosentyx 2023 LCM canakinumab ACZ885 Adjuvant NSCLC 2024 LCM Adakveo SEG101 LCM Aimovig Sickle cell anaemia with crisis ped erenumab, AMG334 Pediatric Migraine ≥2025 LCM Cosentyx LCM Leqvio LCM secukinumab, AIN457 Lupus Nephritis KJX839 CVRR-LDLC LCM Cosentyx LCM Beovu LCM aflibercept BioS secukinumab, AIN457 AS IVIV brolucizumab, RTH258 RVO4 SOK583 Neovascular age-related macular degeneration Cosentyx secukinumab, AIN457 Lichen Planus LCM Mayzent LCM siponimod, BAF312 Pediatric MS LCM Denosumab BioS Coartem LCM Beovu LCM Jakavi LCM Piqray LCM ACZ885 NSCLC 1L secukinumab, AIN457 Hidradenitis suppurativa GP2411 artemether + lumefantrine, COA566 brolucizumab, RTH258 ruxolitinib, INC424 alpelisib, BYL719 anti RANKL mAb Malaria uncompl., formula for <5kg Diabetic retinopathy Myelofibrosis (combination) HER2+ adv BC Cosentyx LCM Entresto EU² LCM Kisqali LCM Cosentyx LCM Kymriah LCM OAV101 LCM secukinumab, AIN457 sacubitril/valsartan, LCZ696 Juvenile idiopathic arthritis Pediatric CHF ribociclib, LEE011 HR+/HER2- BC (adj) secukinumab, AIN457 tisagenlecleucel, CTL019 GCA 1L high risk ALL, pediatrics & young adults AVXS-101 SMA IT Jakavi LCM Tafinlar + Mekinist LCM Lutathera LCM Jakavi LCM ruxolitinib, INC424 Chronic GVHD dabrafenib + trametinib, DRB436 HGG/LGG Pediatrics 177Lu-oxodotreotide³ GEP-NET 1L G3 ruxolitinib, INC424 Pediatrics Acute GVHD Jakavi LCM Xolair LCM Piqray LCM Jakavi LCM ruxolitinib, INC424 omalizumab, IGE025 alpelisib, BYL719 ruxolitinib, INC424 Acute GVHD Auto-injector TNBC Pediatrics Chronic GVHD Kymriah LCM Piqray LCM Leqvio LCM tisagenlecleucel, CTL019 alpelisib, BYL719 KJX839 aNHL 2L Ovarian cancer Ped Hyperlipidemia Kymriah LCM Promacta LCM Tafinlar+ Mekinist LCM tisagenlecleucel, CTL019 eltrombopag, ETB115 r/r Follicular lymphoma Radiation sickness syndrome dabrafenib + trametinib, DRB436 Thyroid cancer Xolair LCM omalizumab, IGE025 Food allergy 1. Depending on timing of final read-out submission may move to early 2022. 2. Approved in US. 3. 177Lu-dotatate in US. 4. Under evaluation. 54 Investor Relations | Q2 2021 Results NOVARTIS | Reimagining Medicine
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