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Investor Presentaiton

Investor presentation First three months of 2017 Slide 83 More than 20 million people in the US have a BMI above 35 with either pre-diabetes or CV related comorbidities Incidence of obesity in the US (million people) Comorbidity status BMI 27-29.9 Class I BMI 30-34.9 Obesity Class II BMI Class III BMI Total 35-39.9 40+ No CV 15.5 11.0 4.2 3.0 33.7 comorbidities¹ CV 15.1 16.0 6.4 comorbidities² 4.1 41.6 Pre-diabetes³ 12.0 14.1 7.2 6.1 39.4 The US obesity burden Cost of obesity to health care systems of USD 147 billion annually with continued growth 5 Around 35% of the US adult population (over 20 years) have obesity (BMI >30)6 Only around 30% of all obesity cases in the US were diagnosed in 20097 In 2010, only 3 million people in the US or around 3% of the adult population with obesity were treated with anti-obesity medication8 Type 2 diabetes4 2.0 5.0 3.6 2.3 12.9 44.6 46.1 21.4 15.5 127.6 Total 1 Normal blood glucose without hypertension and/or dyslipidemia 2 Normal blood glucose with hypertension and/or dyslipidaemia 3 Impaired Fasting Glucose with or without hypertension and/or dyslipidaemia 4 Type 2 diabetes with or without hypertension and/or dyslipidaemia Source: 2009-2010 NHANES + revised 2011 CDC estimates and based on US population 2015. Only includes population age 20+. Distribution between obese groups on market map based on NHANES data (including only measured and not self reported BMI and also measured not self-reported diabetes status) 5 Finkelstein et al. Health Affairs 28, no. 5 (2009): w822-831 6 Flegal, KM. JAMA. 2012;307(5): Doi: 10.1001/jama.2012.39 7 Ma et al. Obesity (Silver Spring) 2009;17:1077-85 8 Obesity. Decision resources, Inc. December 2010:38 novo nordisk
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