Investor Presentation

145 Investor presentation First six months of 2022 Currency impact on Novo Nordisk's P/L Operational currency impact All movements in currencies will directly impact the individual reported functional lines of the Novo Nordisk's P&L statement The currency effect on e.g. operating profit growth is the difference between the reported growth and the operating profit growth at CER Key currencies account for around 65-85% of the total currency exposure No hedging effects are included in the operating profit Sensitivity table gives an indication of gain/loss of a 5% immediate change in exchange rates compared to exchange rates on announcement day Cost of goods sold Gross profit Note: Example is based on Annual Report 2021 Novo NordiskⓇ DKK million 2021 2020 Income statement Net sales 140,800 126,946 (23,658) (20,932) Financial currency impact All gain/losses from hedging contracts are included in the financial income/expenses All key currencies are hedged: • 117,142 106,014 USD 12 months • iSales and distribution costs Research and development costs Administrative costs JPY 12 months (37,008) (32,928) • CAD 9 months (17,772) (15,462) (4,050) (3,958) GBP 11 months Other operating income and expenses 332 460 • CNY 0 months Operating profit 58,644 54,126 Financial income 2,887 1,628 Financial expenses (2,451) (2,624) Profit before income taxes 59,080 53,130 Income taxes (11,323) (10,992) NET PROFIT 47,757 42,138 Basic earnings per share (DKK) 20.79 18.05 Hedging is primarily performed with the use of forward contracts Net financials includes hedging gain/loss including the cost of hedging and the effect from currency gain/losses of balances in non-hedged currencies Hedging costs are the interest rate differentials between DKK and hedged currencies Diluted earnings per share (DKK) 20.74 18.01

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