Fourth-Quarter and Full-Year 2019 Orphan and Rheumatology Segment Results

Driving TEPEZZA Adoption: Our Commercialization Strategy Establish Market structure and simplify patient journey Educate All stakeholders about Thyroid Eye Disease and TEPEZZA Support TEPEZZA.M teprotumumab-trbw TEPEZZA launch with our comprehensive, high-touch, patient-centric model Facilitate Access to TEPEZZA by establishing an infusion site-of-care referral network HORIZON Note: For additional TEPEZZA safety information, please see end of presentation. 18

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