Cboe Results Presentation Deck

4Q20 Net Revenue by Segment and Key Drivers Net Revenue¹ (in millions) $280.3 $139.4 $75.5 30.9 $21.6 $12.9 4Q19 +10% $307.1 $162.5 $73.6 $21.5 $35.5 $14.0 4Q20 Segment Options CBOE - C2 - BZX - EDGX U.S. Equities BYX-BZX- EDGA - EDGX Futures CFE European Equities Europe Lit & Dark - BXTR - LIS-EuroCCP Global FX Spot - Forwards - SEF • Net revenue up 17% Higher trading in multi-listed options and growth of proprietary market data 4Q20 Key Drivers • Net revenue down 3% • Decrease in SIP market data revenue, including lower SIP audit recoveries • Net revenue down 30% • Lower trading volume in VIX futures ● Net revenue up 64% • Addition of EuroCCP ● Cboe ● Net revenue up 9% Growth in transaction and non-transaction revenue Record market share 10

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