ATAI Investor Day Presentation Deck
Preliminary evidence for dose-dependent changes in ERP
ERPS support physiological differences between acute administration of low and high dose groups
RL - 007 may remediate SZ-related deficits in sensory memory at low to moderate doses
With this acute treatment there was no consistent response across timepoints
Significantly increased MMN amplitudes at the lower dose levels (10 & 20 mg) vs salient decrease in MMN amplitudes
at 40 mg
●
No effect on P300b at low doses vs sporadic significantly decreased in P300b amplitudes at the highest dose levels (40
& 80 mg)
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LIFE SCIENCES
MMN8 trough exposure time-point D2 vs D4-PKAMP (20mg)
FZ-LE MMN8_D2_Predose MMN8_D4_Predose
μV
min
-2-
0-
2-
6-
-100 -50
0
50
100
150
200
250 300
350 ms
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Mismatch negativity - passive auditory oddball event-
related potential (ERP)
Salient beneficial changes in MMN amplitude and
latency observed in 20 mg cohort
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