Investor Presentaiton

Q2 2023 HUMALOG SALES DECREASED 1% Millions U.S. sales decreased 4% International sales increased 1% $618 $548 $461 $447 $440 $447 13 WK RA TRX SOM 50% 40% 30% 20% 10% U.S. TRX SOM Lilly Humalog + Insulin Lispro Humalog Lilly Insulin Lispro 0% Q1 Q2 Q3 Q4 Jun 2021 Sep Dec Mar Jun Sep Dec Mar Jun 2021 2021 2022 2022 2022 2022 2023 2023 2022 2023 Not for promotional use Source: IQVIA NPA TRX 3MMA, weekly data June 30, 2023; RA = rolling average 2023 Q2 EARNINGS 33

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