Q3 2022 Results slide image

Q3 2022 Results

Company overview Financial review 2022 priorities Appendix References KisqaliⓇ grows strongly across all regions Increasing recognition of overall survival and quality of life benefits Sales evolution USD m, % CC Ex-US US +49% 7 327 232 193 145 mBC monthly % NBRx share 63 Ibrance® -KisqaliⓇ 1 GROWTH YCE AZ KISQALI KL -VerzenioⓇ 58 56 57 40 53 49 19 33 33 31 31 54 44 33 55 59 557 51 44 43 40 35 33 27 27 28 28 31 31 31 34 26 26 20 18 18 14 15 13 12 13 14 10 134 87 Q3 2021 Q3 2022 Sep Oct Nov Dec Jan Feb Mar Apr May Jun 2021 Jul Aug 2022 mBC Metastatic breast cancer NBRX - New to Brand prescriptions CDK Cyclin Dependent Kinase 1. Of CDK4/6 mBC market, monthly 10 Investor Relations | Q3 2022 Results Sales accelerating: US NBRx share 26% (vs. 10% PY)1 Driven by Kisqali's unique profile: - Only CDK4/6 with overall survival benefit across 3 Ph3 studies - Improved / maintained quality of life in MBC First head-to-head CDK4/6 study (vs. IbranceⓇ HARMONIA): recruitment ongoing; final analysis expected 2026 NATALEE adjuvant study primary analysis expected H2 2023 NOVARTIS | Reimagining Medicine
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