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124 Investor presentation Full year 2022 Insulin market size and volume share of growth and market share in Region China Region China Total Insulin market share and market size (DKK billion) Long- 27% acting Fast- acting 79% 2 52% Premix 84% 4 34% Human 2 5 Novo Nordisk Competitors Market growth A Market share Insulin volume: market share 80% 50% 13 -11.0% +2.9% 40% 60% 48% -17.8% +3.7% 30% 40% 17% 20% -5.7% -1.6% 20% 7% 10% 2% -5.3% +4.1% 0% 0% Nov Nov 2019 2022 -NN market share -8.0% -4.6% Source: IQVIA, Nov 2022, LHS graph - Value, RHS Graph - Volume, MAT; NN: Novo Nordisk; Region China covers Mainland China, Taiwan, and Hong Kong NN share of growth Market growth (right axis) NN growth (right axis)

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