Investor Presentaiton

Investor presentation Full year 2018 Slide 48 The insulin market is comprised of three segments 6:00 10:00 ↑ Breakfast changing diabetes Insulin action profiles tMU 600 Global insulin volume market by segment CAGR volume¹: 4.5% CAGR value¹: 13.7% Fast-acting 500 35% 400 34% Fast-acting Premix 300 25% 200- 29% Premix Long-acting 40% 100 37% Long-acting 0 14:00 18:00 22:00 2:00 6:00 ↑ ↑ Time of day Nov 2013 Nov 2018 Lunch Dinner 1 CAGR for 5-year period. Value in DKK Source: IQVIA monthly MAT volume and value Nov 2018 novo nordisk

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