Investor Presentation First Nine Months of 2022

50 Investor presentation First nine months of 2022 Insulin market size and volume share of growth and market share Insulin market share and market size (DKK billion) Total 44% Long- Acting 37% Fast- 52% 95 Acting 70% Premix 17 33% Human 24 137 Novo Nordisk Competitors Market growth A Market share 273 5.4% +0.3% 50% Insulin volume: Market share Novo NordiskⓇ 47% 10% 40% 7% 5.3% +0.6% 30% 4% 7.6% 0.0% 1% 20% 1% -1% -2% 10% -1.0% +2.0% 0% Aug 2.5% -1.7% 2019 -NN market share Source: IQVIA, Aug 2022, LHS graph - Value, RHS Graph - Volume, MAT, all countries; Share of growth not depicted due to too high numbers; NN: Novo Nordisk -5% Aug 2022 Market growth (right axis) NN growth (right axis)

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