Investor Presentaiton
Targeted Protein Degradation and Cell Therapy: Two
differentiated platforms for optimizing therapies for patients
Targeted Protein Degradation
Molecular
glue
Target
protein
Molecular
glue
molecule
Hetero-
bifunctional
Target
protein
ADC
degrader
Matching modality
to mechanism
Cell Therapy
Autologous
Next-generation
Single CAR
binder
Multiple
other KO/KI
TCR
KO
Dual CAR
binder
E3
ligase
E3 ligase
Cysteine residue
Invention of high-
quality therapeutics
that match a modality
Dual CAR
binder
MHC-I
KO
MHC-II
• Drug-Linker
KO
to a molecular
mechanism of action
CELMOD
LDD
Ill Bristol Myers Squibb™
CELMOD ADC
These two platforms unlock novel targets and mechanisms to efficiently
deliver INDS with the potential to improve the lives of patients
Allogeneic,
iPSC-derived
Not for Product Promotional Use
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