IPTACOPAN ASH UPDATE

On track to launch a potential new standard-of-care in PNH 1 Iptacopan could be practice-changing: ✓ Superior efficacy to anti-C5 therapy ✓ Significant QoL benefits Oral option in infusion market Potential new standard of care 2 On track with launch readiness: Playbook for rare disease launches ✓ Existing relationships with PNH HCPS. Disease education campaign launched ☐ Medical and sales teams in place 30 IPTACOPAN ASH UPDATE | DECEMBER 13, 2022 NOVARTIS | Reimagining Medicine

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