Major R&D Pipeline: 3ADCs slide image

Major R&D Pipeline: 3ADCs

Core Operating Profit Increased by 9.6 Bn JPY (Increased by 6.6 Bn JPY excl. forex impact) FY2020 Results 34.1 Revenue Cost of Sales SG&A Expenses R&D Expenses Forex Impact FY2021 Results 43.7 27.1 Positive Factors 3.6 4.0 7.1 Negative Factors Revenue incl. forex impact of +6.6 Cost of Sales +27.1 +2.8 (Profit decreased) Daiichi-Sankyo (Bn JPY) Improvement in cost of sales ratio by change in product mix 2.8 SG&A Expenses +7.1 (Profit decreased) Increase in expenses related to Enhertu due to an increase in profit share of gross profit with AstraZeneca R&D Expenses +4.0 (Profit decreased) Increase in 3ADCS* R&D investments Forex Impact +3.6 (Profit decreased) Cost of Sales +0.1 SG&A Expenses +2.3 R&D Expenses +1.2 * 3ADCs: 1) Enhertu, Trastuzumab deruxtecan (T-DXd, DS-8201), 2) Datopotamab deruxtecan (Dato-DXd, DS-1062) and 3) Patritumab deruxtecan (HER3-DXd, U3-1402) 6
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