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FIRST QUARTER 2022 FINANCIAL HIGHLIGHTS 1Q 2022 1Q 2021 Net Sales $9.0M $6.8M Gross Profit $460K $647K Gross Profit Margin 5.1% 9.5% Operating Loss $(8.1) M $(5.2)M 22ND CENTURY GROUP Net Loss $(8.9)M $(5.0)M CMO activities fund the cost of facilities needed to manufacture VLNⓇ. 24

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