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Investor Presentaiton

R&D investor presentation 42 We continue progressing on the strategic aspirations Purpose and sustainability ༢ Commercial execution 0 Being respected for adding value to society Progress towards zero environmental impact Ensure distinct core capabilities and evolve culture • • Patient flows impacted by COVID-19, but early signs of recovery Early RybelsusⓇ uptake further supports GLP-1 NBRX and TRX market leadership in the US While barriers in the obesity market still remain, recent readouts are important milestones to achieve the aspiration of more than doubling obesity sales¹ III Financials Innovation and therapeutic focus ⚫||||| • • • • • Once-weekly insulin progressing to phase 3 Semaglutide showed encouraging profile in NASH Strategic expansion into CVD with acquisition of Corvidia Semaglutide 2.4mg in obesity phase 3 results Promising result of AM833 and Semaglutide in obesity Deliver solid sales and operating profit growth • Deliver 6-10% sales growth in IO Transform 70% of sales in the USA² Drive operational efficiencies across the value chain to enable investments in future growth assets Deliver free cash flow to enable attractive capital allocation to shareholders 1 Based on reported sales in 2019, 2 From 2015 to 2022. IO: International Operatons; CVD: Cardiovascular disease; NASH: Non-alcoholic steatohepatitis; CKD: Chronic kidney disease.
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