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Investor Presentaiton

Investor Presentation First nine months of 2018 Slide 39 Region Japan & Korea at a glance Diabetes market by value and Novo Nordisk market share Diabetes trend in population Million 16 Population with diabetes Diabetes growth rate NN Insulin MS NN OAD MS bDKK 40 Novo Nordisk reported sales NN GLP-1 MS First nine months of 2018 Sales (mDKK) YTD growth² 80% Long-acting insulin³ 637 4% 9% 0% > Premix insulin4 483 (1%) I 12 30 27.6%¹ nsum 60% Fast-acting insulin5 578 (13%) 12 12 11 Human insulin 140 (17%) 8 (3.1%)¹ 20 40% Total insulin 1,838 (5%) GLP-16 440 7% 4.2%¹ Other diabetes care? 274 0% 10 - 20% OAD Diabetes care 2,552 (3%) Obesity (SaxendaⓇ) 72 0 2000 2017 2045 Aug 2013 0% Biopharm³ 1,563 (7%) Aug 2018 Total 4,187 (3%) Japan & Korea population 2018: ~0.2 billion people and diabetes prevalence ~8.0% Source: International Diabetes Federation: Diabetes Atlas 1th Edition 2000 and Diabetes Atlas 8th Edition 2017 1 CAGR calculated for last 5-year period Competitor value market share for insulin as of Aug 2018: Eli Lilly 22% and Sanofi 21% Competitor value market share for GLP-1 as of Aug 2018: Eli Lilly 59% and AstraZeneca 4% OAD: Oral anti-diabetic; MS: Market share Source: IQVIA MAT Aug, 2018 value figures 2 Percentage change in local currency from YTD Q3 2017 to YTD Q3 2018 3 Comprises TresibaⓇ and Levemir®; 4 Comprises NovoMix® and RyzodegⓇ 5 Comprises NovoRapid®; 6 Comprises VictozaⓇ; 7 Comprises NovoNormⓇ and needles; 8 Comprises primarily NovoSevenⓇ, NovoEight® NovoThirteenⓇ and NorditropinⓇ
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