Investor Presentaiton

2 Near-term Clinical Validity & Utility Cohorts Plasma Timepoints 80K MRD samples for Smart Liquid Biopsy clinical studies Gastric Pancreatic GUARDANT™ INVESTOR 20 DAY 23 Indication Description Patients CRC COSMOS >300 >2,000 10 monitoring Breast Multi-center >1000 >3,000 17 Multi-center >300 >300 Solid tumor Lung Single center >300 >700 types Breast - TNBC Single center >100 >500 Breast Mixed - Single center >200 >1,500 Multi-center >400 >2,000 18K Multi-center >400 >2,000 Patients Head & Neck Multi-center >115 >700 99 66

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